Research by R. G. Coss and others found that people who did not run away from pumas had the greatest frequency of being severely injured (43%) and the lowest likelihood of escaping injury (26%). In other words, if a puma is approaching you...

Imagine we are playing monopoly. When it is my turn I roll the die five times in a row then choose the roll I prefer, the one which places my piece on a winning square. Wouldn’t you tell me I cannot do that, accuse me of cheating and walk off? It stands to reason that we should not tolerate the equivalent, the changing of endpoints to gain better results, in clinical trials.